NABP NAPLEX North American Pharmacist Licensure Examination Exam Practice Test

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Total 155 questions
Question 1

Mesna is typically administered alongside which of these chemotherapeutic agents?



Answer : C

Mesna is administered to patients taking either ifosfamide or cyclophoshamide to conjugate toxic acrolein and therefore prevent hemorrhagic cystitis (bladder bleeding).


Question 2

What is the mechanism of action of the active ingredient found in Zyflo?



Answer : B

Zileuton is the active ingredient found in the medicine Zyflo; a medicine that works as a 5-lipoxygenase inhibitor. As such, zileuton inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, and is used for the maintenance treatment of asthma in patients older than the age of 12. In 2 percent of patients, it raises liver enzymes. Sinusitis and nausea are the most common side effects.


Question 3

A CD4 count of 180 cells per cubic meter may be evaluated as which of these?



Answer : A

A CD4 count of 180 cells per cubic meter is considered very low -- typically an indicator that the patient has an immunocompromised state, such as AIDS. CD4 counts are a measure of healthy T-cell levels. The lower the count, the more susceptible the patient is to opportunistic infections. A normal range is between 500 and 1,500 cells.


Question 4

A patient with acute pharyngitis caused by group A Streptococcus (strep throat) is allergic to penicillins (non- immediate type), which of the following is NOT recommended as treatment?



Answer : B

Amoxicillin is a penicillin and so should be avoided in patients even with a non-immediate allergy. Acute treatment should be administered with one of the other listed options.


Question 5

How does pregabalin work in the treatment of seizures?



Answer : B

Pregabalin works as a ligand of the auxiliary 2 subunit site of certain voltage-dependent calcium channels (VDCCs), and thereby acts as an inhibitor of 2 subunit-containing VDCCs.


Question 6

Which of the following side effects should LT be made aware of while on Divalproex Sodium?



Answer : C

Common GI side effects of Valproic Acid and Divalproex Sodium are Weight gain, Nausea, Vomiting, Diarrhea, abdominal pain, dyspepsia. Divalproex sodium or valproic acid affects reproductive endocrine function in women. Menstrual irregularities defined as amenorrhea, oligomenorrhea, and prolonged cycles were common. Gynecomastia is not a side effect of Divalproex Sodium. For list of drugs that causes gynecomastia refer the reference. Gingival hyperplasia is a well-known side effect of phenytoin.


http://www.pharmaco-vigilance.eu/content/drug-induced-gynecomastia

Question 7

Which of the following Anti-epileptic medication can cause pancreatitis?



Answer : C

Cases of life-threatening pancreatitis have been reported in both pediatric and adult patients receiving valproic acid or its analogs. Patients should be warned that abdominal pain, nausea, vomiting, and/or anorexia can be symptoms of pancreatitis that require prompt medical evaluation. If pancreatitis is diagnosed, valproate should be discontinued.


http://www.clinicalpharmacology-ip.com/Forms/Monograph/monograph.aspx?cpnum=637&sec=moncontr&t=0

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Total 155 questions